Solid-state NMR spectroscopy

Solid-state nuclear magnetic resonance (NMR) spectroscopy is an atomic-level method to determine the chemical structure, 3D structure and dynamics of solids semi-solids. This Primer summarizes basic principles NMR as applied wide range solid systems. The spin interactions effects fields radiofrequency pulses on spins in solid-state are same liquid-state spectroscopy. However, because orientation dependence state, majority high-resolution spectra measured under magic-angle spinning (MAS), which has profound types pulse sequences required extract structural dynamical information. We describe most common MAS experiments data analysis approaches for investigating biological macromolecules, organic materials inorganic solids. Continuing development sensitivity-enhancement approaches, including 1H-detected fast experiments, dynamic polarization ultra-high fields, described. highlight recent applications chemistry. ends with a discussion current limitations well areas points emerging this sophisticated used semi-solids biology, chemistry sciences.